dowser-package - dowser: B Cell Receptor Phylogenetics Toolkit

Description¶

Provides a set of functions for inferring, visualizing, and analyzing B cell phylogenetic trees. Provides methods to 1) reconstruct unmutated ancestral sequences, 2) build B cell phylogenetic trees using multiple methods, 3) visualize trees with metadata at the tips, 4) reconstruct intermediate sequences, 5) detect biased ancestor-descendant relationships among metadata types Workflow examples available at documentation site (see URL). Citations: Hoehn et al (2022) \Sexpr[results=rd]{tools:::Rd_expr_doi(“#1”)}10.1371/journal.pcbi.1009885latexhttps://doi.org/10.1371/journal.pcbi.1009885doi:10.1371\slash{}journal.pcbi.1009885https://doi.org/10.1371/journal.pcbi.1009885doi:10.1371/journal.pcbi.1009885 , Hoehn et al (2021) \Sexpr[results=rd]{tools:::Rd_expr_doi(“#1”)}10.1101/2021.01.06.425648latexhttps://doi.org/10.1101/2021.01.06.425648doi:10.1101\slash{}2021.01.06.425648https://doi.org/10.1101/2021.01.06.425648doi:10.1101/2021.01.06.425648 .

See also¶

Useful links:

• https://dowser.readthedocs.io
• Report bugs at https://github.com/immcantation/dowser/issues

Author¶

Maintainer: Kenneth Hoehn kenneth.b.hoehn@dartmouth.edu

Authors:

• Kenneth Hoehn kenneth.b.hoehn@dartmouth.edu
• Cole Jensen cole.jensen@yale.edu
• Jessie Fielding jessie.jo.fielding@dartmouth.edu
• Hunter Melton hunter.j.melton@dartmouth.edu
• Steven Kleinstein steven.kleinstein@yale.edu [copyright holder]

Other contributors:

• Susanna Marquez susanna.marquez@yale.edu [contributor]
• Jason Vander Heiden jason.vanderheiden@gmail.com [contributor]
• Erick Matsen [contributor]